Description

Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. The main object of action of sarolaner in insects and acarids is the functional blockade of ligand-dependent chloride channels (GABA receptors and glutamate receptors). Sarolaner blocks GABA and glutamate-dependent chloride channels in the central nervous system of insects and acarids. Disruption of these receptors by Sarolaner prevents the absorption of chlorine ions by GABA and glutamate-dependent ion channels, which leads to increased nerve stimulation and death of the target parasite. Sarolaner demonstrates a higher functional ability to block insect / acarid receptors than mammalian receptors. Sarolaner does not interact with known insecticidal binding sites of nicotine or other GABAergic insecticides, such as neonicotinoids, fiproles, milbemycins, avermectins and cyclodienes

In this fixed combination, moxidectin and pyrantel provide additional anthelmintic efficacy due to different mechanisms of action. In particular, both active substances contribute to the overall effectiveness against gastrointestinal nematodes Ancylostoma caninum and Toxocara canis.

100 mg of the drug contains active substances:

• sarolaner – 1.333 mg
• moxidectin – 0.027 mg
• pyrantel (as pyrantel embonate) – 16.013 mg.