Description

Doxycycline, which is part of the drug, belongs to the semi-synthetic antibiotics of the tetracycline group with a wide spectrum of action, is active against gram-positive and gram-negative microorganisms, incl. Escherichia coli., Yersinia enterocolitica, Bordettela pertussis, Shigella spp., Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp., Streptococcus spp., Klebsiella pneumoniae, Leptospira spp., Clostridium spp. , Erysipelothrix rhusiopathiae, Fusobacterium necroforum, Actinobacillus spp., Rickettsiae spp., Chlamidia spp, and Mycoplasma spp.

The mechanism of the bacteriostatic action of doxycycline is associated with the inhibition of enzymes that catalyze the binding of aminoacetyl RNA to ribosomal acceptors, which leads to blocking the interaction of aminoacyltransport RNA with messenger RNA and disruption of microbial cell protein synthesis.

After parenteral administration of the drug, doxycycline is well and rapidly absorbed from the injection site, reaching therapeutic concentrations in 0.5-1 hour; easily penetrates into most organs and tissues of the animal, metabolized in the liver with the formation of inactive metabolites. It is excreted from the body mainly with bile and partly with urine.