Description

Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. The main object of action of sarolaner in insects and acarids is the functional blockade of ligand-dependent chloride channels (GABA receptors and glutamate receptors). Sarolaner blocks GABA and glutamate-dependent chloride channels in the central nervous system of insects and acarids. Disruption of these receptors by Sarolaner prevents the absorption of chlorine ions by GABA and glutamate-dependent ion channels, which leads to increased nerve stimulation and death of the target parasite. Sarolaner demonstrates a higher functional ability to block insect / acarid receptors than mammalian receptors. Sarolaner does not interact with known insecticidal binding sites of nicotine or other GABAergic insecticides, such as neonicotinoids, fiproles, milbemycins, avermectins and cyclodienes.

After application of the drug, the lethal effect on ticks that parasitize the animal and new invasions begins within 48 hours.

For fleas, the onset of effective action of the drug occurs 12-24 hours after application and lasts 5 weeks. Fleas that have already parasitized the animal die 8 hours after application of the drug. The veterinary drug kills new fleas on the dog before they can lay eggs, and therefore it prevents flea contamination of the environment in places where the dog has access.