Description

Doxycycline is a semi-synthetic antibiotic of the tetracycline group of the second generation, active against gram-positive (Staphylococcus spp., Streptococcus spp., Corynebacterium spp., Clostridium spp., Bacillus anthracis, Erysipelothrix spp., Listeria spp., Enterococcus spp.) and gram-negative (Actinomyces spp. ., Fusobacterium spp., Pseudomonas spp., Pasteurella spp., Eikenella spp., Enterobacteria spp., Moraxella spp., Brucella spp., Bartonella spp., Proteus mirabilis, Escherichia coli, Citrobacter, Serratia, Bacteroides tectum, Salmonella) microorganisms : as well as mycoplasma (for example, Mycoplasma haemofelis), spirochetes, chlamydia and rickettsia. Auxiliary means for the treatment of dogs with heartworm disease, as it eliminates symbiosis with Wolbachia.

The mechanism of bacteriostatic action of doxycycline is associated with inhibition of enzymes that catalyze binding of aminoacetyl-RNA to ribosomal acceptors. This, in turn, leads to the blocking of the interaction of the aminoacyl transport RNA with the 30S-subunit of the ribosomal membrane and disruption of the protein synthesis of the microbial cell.